Figure 1
Age-related effect on gut Microbial diversity and composition of hospitalized patients’ with suspected infectious diarrhea. (A) Phylogenetic diversity (a measure of within sample diversity, or α-diversity) of hospitalized Israeli patients’ fecal microbiome OTU relative abundance plotted against age, for all sample across all ages, with a local polynomial regression fitting calculated by weighted least squares method, and a 0.95 confidence interval using a t-based approximation. Dark-shaded box represents years 0–4. Light-shaded box represents years 4–25. Right inset represent the same calculation during the first 25 years of life, with a linear regression fitting. Left inset, a boxplot for the first 4 years of life (0–< 4). (B) Fold change in taxonomic abundance between adults (18–70 years) and infants and toddlers (0–< 4 years). A fold change greater than one represents a gain in adults, and lower than one a gain in children and toddlers. Results are shown for taxa with a significant change over age, as inferred by a MaAsLin analysis (see methods), at the genus (g) level, for taxa from the phylum Proteobacteria, Firmicutes, Bacteroidetes, and Actinobacteria.
