Figure 6
BDNF treatment increased the number and length of RBC ectopic dendrites and the ERG responses in RCS rats. Immunostaining of PKCα in the retinae of P60 RCS rats, five weeks after (a) PBS (control) or (b) BDNF treatment. Bottom sub-panel shows magnification of the dotted area in the top right subpanel. Arrows indicate ectopic dendrites. (c) Number of RBC ectopic dendrites in retinae of RCS rats, five weeks after PBS or BDNF treatment, per field view (213 µm × 213 µm) (bars show means; error-bars, SEM; n = 5). (d) Same for length of ectopic dendrites (n = 5) (e) Representative ERG traces in RCS rats, five weeks after subretinal injection of PBS or BDNF. (f) Group data for the amplitude of a-waves (top) and b-waves (bottom) from ERG recordings in RCS rats, five weeks after surgery (bars, means; error-bars, SD; n = 10). ONL: outer nuclear layer; OPL: outer plexiform layer; INL: inner nuclear layer; GCL: ganglion cell layer. *p < 0.05; #p < 0.01.
