Figure 7 | Scientific Reports

Figure 7

From: Functional ectopic neuritogenesis by retinal rod bipolar cells is regulated by miR-125b-5p during retinal remodeling in RCS rats

Figure 7

Regulation of RBC ectopic dendrites by the BDNF-TrkB-CREB pathway in RCS rats. (a) Immunostaining for TrkB and PKCα in the retinae of P36 RCS rats. (b) Immunostaining for CREB and PKCα in the retinae of P36 RCS rats. (c) Western blot assay of retinal serial sections in P60 RCS rats, five weeks after AAV-125b or BDNF treatment. The control group consisted of untreated retinae. GAPDH was used as a loading control. The dotted box indicates the position of the OPL and ONL. For original blot images, please see Supplementary Fig. 14. (d) The normalized expression of TrkB and CREB in the retinal fractions (bars show means; error-bars, SD; n = 3). ONL: outer nuclear layer; OPL: outer plexiform layer; INL: inner nuclear layer; GCL: ganglion cell layer. *p < 0.05.

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