Figure 3 | Scientific Reports

Figure 3

From: A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic

Figure 3The alternative text for this image may have been generated using AI.

Neurosphere assay (A,B): Treatment of neural precursor cell population from postnatal (P2–3) mouse hippocampus by novel compounds in ex vivo assay shows the neurogenic potential only in #3; results are expressed as mean ± SEM, where neurosphere frequency (>100 μm size) is represented as percentage of control (n = 3/group); *p < 0.05 compared with the control (student’s t-test). (C,D) Shown are representative photomicrographs of Nestin +ve cells (C, top panel) and BrdU +ve cells (C, bottom panel) from vehicle -(DMSO 1%) and compound treated groups. (D) Number of Nestin +ve and BrdU +ve cells in the SGZ at the border of the granule cell layer (n = 4–5/group), *p < 0.05 compared with vehicle (student’s t-test).

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