Figure 1
From: Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease
Cross sectional data (LOESS regression analysis and the estimates and their 95% confidence limits were drawn) of body-mass index (BMI) in preclinical (CDR = 0) mutation carriers (MCs) and non-mutation carriers (NCs) in relation to the estimated years to onset (EYO). A significant difference in BMI between MCs and NCs is detected in the area where the estimated 95% confidence intervals for the regression lines don’t overlap (−11.2 years). The intersection points of the lower and upper confidence interval borders were calculated by a numerical approximation. This method was also used to detect the point, at which the two curves begun to diverge (−17.8 years). The use of scatter plots is not permitted with DIAN data as the data points can be very specific to an individual and may allow to identify its mutation status.
