Table 1 Baseline demographics, body mass index, clinical, cognitive, biochemical and imaging parameters in preclinical (CDR = 0) mutation carriers (MCs) and non-carriers (NCs).

Age

36.7 (7.9)

35.3 (8.0)

0.238^a

Gender (M/F) no.

49/72

64/88

0.789^b

Education (years)

13.2 (0.4)

13.4 (0.6)

0.735^a

GDS

1.3 (1.8)

1.6 (1.9)

0.248^c

EYO

−11.8 (7.1)

−11.5 (6.7)

0.759^a

BMI, kg/m²

30.1 (5.9)

26.5 (5.2)

0.0001 ^a

BMI < 18.5 (%)

1.1

2.1

0.984^b

BMI ≥ 18.5 to <25.0 (%)

24.7

34.0

0.165^b

BMI ≥ 25.0 to <30.0 (%)

30.3

38.1

0.263^b

BMI ≥ 30 (%)

43.8

25.8

0.009 ^b

Stroke (%)

1.1

0

0.443^d

Diabetes (%)

2.2

0

0.195^d

Hypertension (%)

16.9

5.4

0.010 ^d

Hypercholesterolemia (%)

11.2

15.2

0.533^d

MMSE score

29.1 (1.5)

29.1 (1.4)

0.695^a

LogMem I

15.01 (4.2)

13.8 (4.8)

0.037^a

LogMem II

13.9 (4.4)

12.03 (5.3)

0.003 ^a

Global PIB-uptake

1.03 (0.1)

1.7 (0.8)

<0.0001 ^a