Table 1 Multiple comparisons of genotype effects and possible modes of inheritance.

From: Variants in the IL7RA gene confer susceptibility to multiple sclerosis in Caucasians: evidence based on 9734 cases and 10436 controls

Mode of inheritance

MM vs. WW

MW vs. WW

MM vs. MW

(OR1)*

(OR2)

(OR3)

Dominant

+

+

−

Recessive

+

−

+

Complete overdominant#

−

+

+

Codominant

++

+

+

  1. Note: MM: homozygous mutant genotype; MW: heterozygous mutant genotype; WW: wild genotype.
  2. *ORi is pooled odds ratio, complete overdominant model: OR2 is at a lesser risk than both OR1 and OR3. +means a significant result; + + means the effect size is greater than +; − means a non-significant result.
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