Table 4 Meta-analysis of IL7RA polymorphisms on MS.
IL7RA variants | Genetic comparison | I 2(%) | Effect model | OR (95%CI) | P OR | Egger's test (t, p) | Statistical Power |
|---|---|---|---|---|---|---|---|
rs3194051 (8) | GG vs. AA | 31 | Fixed | 1.21 (1.06, 1.37) | <0.01 | ||
GA vs. AA | 0 | Fixed | 0.97 (0.90, 1.03) | 0.32 | |||
GG vs. GA | 76 | Random | 1.17 (1.02, 1.33) | 0.02 | |||
GG vs. AA + GA # | 43 | Fixed | 1.22 (1.08, 1.38) | <0.01 | (0.61, 0.56) | 0.99 | |
rs987107 (6) | TT vs. CC | 0 | Fixed | 1.41 (1.20, 1.67) | <0.01 | ||
TC vs. CC | 0 | Fixed | 0.96 (0.88, 1.05) | 0.34 | |||
TT vs. TC | 0 | Fixed | 1.48 (1.25, 1.75) | <0.01 | |||
TT vs. CC + TC # | 0 | Fixed | 1.44 (1.22, 1.69) | <0.01 | (−0.21, 0.85) | 1.00 | |
rs11567686 (5) | GG vs. AA | 0 | Fixed | 1.23 (0.98, 1.56) | 0.07* | ||
GA vs. AA | 0 | Fixed | 1.16 (0.99, 1.36) | 0.06* | |||
GG vs. GA | 0 | Fixed | 1.05 (0.85, 1.30) | 0.63 | |||
GG + GA vs. AA # | 0 | Fixed | 1.18 (1.01, 1.37) | 0.03 | (2.47, 0.09) | 0.87 | |
rs11567685 (8) | CC vs. TT | 0 | Fixed | 0.96 (0.78, 1.18) | 0.72 | (−1.05, 0.34) | 0.09 |
CT vs. TT | 21 | Fixed | 0.90 (0.81, 1.00) | 0.06* | (−1.54, 0.18) | 0.77 | |
CC vs. CT | 0 | Fixed | 1.05 (0.85, 1.30) | 0.63 | (−0.09, 0.93) | 0.08 | |
C vs. T | 17 | Fixed | 0.94 (0.87, 1.02) | 0.15 | (−1.69, 0.14) | 0.56 | |
CC + CT vs. TT | 22 | Fixed | 0.91 (0.82, 1.01) | 0.07* | (−1.70, 0.14) | 0.72 | |
CC vs. TT + CT | 0 | Fixed | 1.00 (0.82, 1.22) | 1.00 | (−0.62, 0.56) | 0.05 |
