Figure 1 | Scientific Reports

Figure 1

From: Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib

Figure 1

Mechanism of activation of the EGFR L858R and EGFR 19del. Snapshot of EGFR L858R (top left) and EGFR 19del (top right highlighting the catalytically important salt bridge/interactions between K745 and E762 and a new interaction observed between R858 and E758 during the MD simulations. Probability distributions of distances (A) R858-E758 (B) K872-E758 sampled during MD simulations of EGFR WT, EGFR L858R and EGFR 19del.

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