Table 1 Hub genes in the Yellow module.

From: A Systems Genetics Approach Identified GPD1L and its Molecular Mechanism for Obesity in Human Adipose Tissue

Gene

Gene-level p-valuea

GS

GS p-value

MM

MM p-value

Rankb

miRNA

r c

p-value

FDR

GPD1L

2.67E-02

−0.23

1.06E-03

0.90

1.29E-71

1

hsa-miR-210

−0.17

7.37E-03

7.91E-02

CCDC50

2.12E-02

−0.20

4.68E-03

0.85

6.79E-58

2

hsa-miR-501-3p

−0.19

3.93E-03

5.05E-02

NAALAD2

8.05E-03

−0.24

5.76E-04

0.85

1.47E-57

3

hsa-miR-140-3p

−0.29

1.97E-05

7.98E-04

ALDH1L1

4.94E-03

−0.28

7.13E-05

0.85

3.15E-57

4

hsa-miR-342-5p

−0.27

5.13E-05

1.76E-03

ADH1B

3.14E-02

−0.27

8.82E-05

0.85

4.39E-56

5

—

—

—

—

ADH1A

5.00E-02

−0.26

1.83E-04

0.82

2.34E-50

6

hsa-miR-590-3p

−0.09

1.06E-01

4.46E-01

PCCA

2.38E-02

−0.21

2.68E-03

0.82

3.87E-49

8

hsa-miR-301b

−0.25

2.08E-04

5.42E-03

ORMDL3

3.87E-03

−0.29

3.04E-05

0.80

3.29E-45

9

hsa-miR-362-3p

−0.20

2.12E-03

3.23E-02

EPB41L4Bd

7.42E-05

−0.29

3.47E-05

0.67

2.63E-27

28

has-miR-3613-3p

−0.11

6.46E-02

3.4E-01

  1. GS, gene significance; MM, module membership. aGene-level p-value generated by ProxyGeneLD in the GIANT GWAS. bRank based on MM. cCorrelation betwwen miRNA and mRNA. For gene ADH1B, there was no predicted miRNA-mRNA target pair in the MicroCosm database. dOne of 97 BMI loci identified by GIANT.
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