Figure 2 | Scientific Reports

Figure 2

From: Detecting the Molecular System Signatures of Idiopathic Pulmonary Fibrosis through Integrated Genomic Analysis

Figure 2The alternative text for this image may have been generated using AI.

Variation in differential expression of most confident Set A genes along with their first neighbors during IPF progression. (A) Normal to Early IPF shifts in differential expression, (B) Early to advanced IPF shifts in differential expression, (C) Normal to Advanced IPF shift in differential expression, (D) differentially expressing genes in NSIP and in (E) Sarcoidosis. Green color depicts the degree of overexpression whereas red shows degree of underexpression, (F) Critical chain of five serially connected genes (ACADL-HMGCR-FLT1-FZD5-ARRB1) which appeared downregulated in IPF specifically. This chain is broken in Sarcoidosis due to upregulation of FLT1 while in case of NSIP, the chain is not completely formed. Eight TFs and nine miRNAs appeared crucial in regulating IPF through these check points.

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