Figure 6 | Scientific Reports

Figure 6

From: Interactome and reciprocal activation of pathways in topical mesenchymal stem cells and the recipient cerebral cortex following traumatic brain injury

Figure 6The alternative text for this image may have been generated using AI.

Analysis of gene of MSC and penumbra cortex at day 3 following TBI. Hierarchical clustering of gene expression of MSC pellets before and after topical application on TBI brain and normal brain. Gene lists were generated by comparing MSC pellet versus topical MSCs on TBI brain and topical MSCs on normal brain using moderate T-test and 2-fold filtering in GeneSpring. Down-regulated genes were shown in blue and up-regulated genes were shown in red (6A). Venn diagram illustrated the number of genes which were up- or down-regulated of topical MSCs on TBI brain and normal brain using moderate T-test and 2-fold filtering in GeneSpring. Overlapping area indicated genes from MSCs pellets were coherently altered in both conditions (6B). Cluster analysis of PCR-array on 84 genes associated with neurogenesis in penumbral cortex treated topical MSCs (6C). Compared with control, 13 genes were significantly up-regulated (p < 0.05) (6D). 6 out of 13 genes were up-regulated with equal or more than 1.5 fold (6E). Diagram of the six-gene network which was proposed to get involved in the neurogenesis mediated by the topical MSCs. Grey color genes participated in the network but they were not detected by the PCR-array (6F).

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