Figure 5 | Scientific Reports

Figure 5

From: Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia

Figure 5

TKI gefitinib inhibits NF-κB activity induced by bacterial cell wall components, but not endotoxin. Relative NF-κB activity in HEK293 cells stably expressing Nod1, pre-incubated with gefitinib (1 or 5 μM) and stimulated with FK565 (10 μg/mL) (A), or in HEK293 cells stably expressing Tlr4, pre-incubated with gefitinib (1 or 5 μM) and stimulated with LPS (0.5 μg/mL) (B) n = 12. Values are mean ± SEM. Different letters assigned to each condition (a, b, c) denote statistical differences between groups (p < 0.05).

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