Figure 2 | Scientific Reports

Figure 2

From: Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia

Figure 2

Gria1 āˆ’/āˆ’ and WT mice show similar, successful acquisition of discrimination performance during the trace interval. Panels a–c show responding in the trace interval between the termination of the CS+ and presentation of food as a ratio of the total responding to the CS+ trace interval and the equivalent period after the CSāˆ’. Scores above 0.5 indicate greater responding to the CS+ than CSāˆ’, whereas scores below indicate greater responding to CSāˆ’ than CS+. The dashed line indicates chance performance. Performance is shown across blocks of three sessions. Panels d–f show the raw rates of responding (time in magazine as a percentage of the trace interval) from which the discrimination ratios were calculated. Performance during the trace interval is shown in panels a and d, collapsed across trace interval (4 and 8 s). The performance during theĀ trace interval for the 4 and 8 s conditions is shown separately in panels b and e, and c and f, respectively. Error bars indicate ±S.E.M.

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