Figure 5
From: Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia
Effect of AT1R and A2AR blocking in the TD animal model. The effect of different doses of losartan (a) or istradefylline (b) on total vacuous chewing movements (VCM) in the reserpine-based animal model of TD in mice was monitored during 10 min. (c) Effects of sub-effective dose co-administration (i.p.) of losartan (0.05 mg/ml) and istradefylline (0.03 mg/ml) in the VCM of TD animal model. (d) Effect of losartan in the VCM of TD animal model performed in A2AR-KO mice. Results are represented as the mean ± SEM (n = 10 animals). *P < 0.05 compared to the vehicle group (one-way ANOVA, followed by Newman-Keuls test).
