Table 3 Relationships between APOE genotype and longitudinal changes in cognitive function

From: Protective effects of APOE e2 against disease progression in subcortical vascular mild cognitive impairment patients: A three-year longitudinal study

 

APOE3 homozygote

APOE2 carrier

APOE4 carrier

ß (SE)

p value

ß (SE)

p value

K-MMSE

Ref

0.79 (0.299)

0.009

−0.38 (0.516)

0.459

CDR-SOB

Ref

0.15 (0.271)

0.572

0.01 (0.238)

0.973

Language function

Ref

2.01 (0.646)

0.002

0.03 (0.977)

0.976

Visuospatial function

Ref

1.82 (1.103)

0.098

1.09 (0.707)

0.122

Memory function

Ref

0.97 (1.930)

0.616

3.45 (2.015)

0.087

Frontal-executive function

Ref

0.36 (0.990)

0.715

1.71 (1.079)

0.112

  1. Generalized estimating equation with linear model conducted with cognitive function as the dependent variables and APOE genotype as the independent variables after controlling for age, gender, and education.
  2. APOE = apolipoprotein E; β = unstandardized beta coefficient; SE = standard error; Ref = reference; K-MMSE = Korean version of mini-mental state examination; CDR-SOB = clinical dementia rating-sum of box.
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