Table 2 Regional assessment of R1. General linear models repeated over hemisphere were used to assess the effect of group in regional R1.

ROI	MDD		CTL		F	p-value	Partial η ²
ROI	M/EMM	SE	M/EMM	SE	F	p-value	Partial η ²
Without whole-brain R1 covariate
NAcc	0.635	0.004	0.650	0.004	7.33	0.008	0.09
LPFC	0.734	0.004	0.745	0.004	4.40	0.039	0.05
Insula	0.628	0.002	0.634	0.002	3.62	0.061	0.05
sgACC	0.610	0.004	0.625	0.004	5.69	0.019	0.07
mPFC	0.726	0.004	0.734	0.004	1.57	0.214	0.02
Lateral striate^a	0.665	0.009	0.675	0.009	0.65	0.421	0.01
Lateral extrastriate^a	0.718	0.005	0.726	0.005	1.38	0.244	0.02
Medial striate^a	0.740	0.005	0.749	0.005	2.02	0.160	0.03
Medial inferior extrastriate^a	0.641	0.005	0.647	0.005	0.80	0.374	0.01
Medial superior extrastriate^a	0.681	0.005	0.695	0.005	4.22	0.043	0.05
Whole-brain R1 covariate
NAcc	0.636	0.004	0.649	0.004	5.89	0.018^b	0.07
LPFC	0.738	0.003	0.741	0.003	0.59	0.445	0.01
Insula	0.630	0.002	0.632	0.002	0.86	0.358	0.01
sgACC	0.614	0.004	0.622	0.004	2.15	0.147	0.03
mPFC	0.731	0.003	0.729	0.003	0.35	0.555	0.01
Lateral striate^a	0.672	0.008	0.668	0.008	0.10	0.758	0.00
Lateral extrastriate^a	0.723	0.004	0.721	0.004	0.04	0.848	0.00
Medial striate^a	0.745	0.003	0.744	0.003	0.01	0.920	0.00
Medial inferior extrastriate^a	0.644	0.004	0.644	0.004	0.00	0.949	0.00
Medial superior extrastriate^a	0.686	0.004	0.690	0.004	0.65	0.421	0.01

MDD = Major Depressive Disorder group; CTL = healthy control group; R = right; L = left; ROI = region of interest; M/EMM = mean or estimated marginal mean, EEM computed when covarying for whole-brain R1; SE = standard error; F = general linear model F-statistic for the effect of group; LPFC = lateral prefrontal cortex; sgACC = subgenual anterior cingulate cortex; mPFC = medial prefrontal cortex; ^a = visual network control regions; ^b = when including the whole-brain R1 covariate only the NAcc exhibited a significant effect of group.

Quick links

Search