Table 3 R1 and the number of depressive episodes of Major Depressive Disorder. Median split was used to create two groups of MDD participants based on the number of prior depressive episodes. The more episodes group included individuals with 6 or more episodes (N = 17), and the fewer group 5 or less episodes (N = 22).

ROI	More Episodes		Fewer Episodes		t-statistic	p-value	Cohen’s d
ROI	M	SE	M	SE	t-statistic	p-value	Cohen’s d
Whole-brain	0.761	0.005	0.758	0.004	0.57	0.573	0.19
NAcc	0.635	0.005	0.636	0.006	0.12	0.904	0.04
LPFC	0.725	0.006	0.741	0.005	2.12	0.042^b	0.68
Insula	0.623	0.003	0.632	0.003	1.82	0.077	0.58
sgACC	0.613	0.008	0.608	0.007	0.49	0.624	0.16
mPFC	0.716	0.006	0.734	0.006	2.08	0.045^b	0.67
Lateral striate^a	0.671	0.016	0.660	0.014	0.52	0.606	0.16
Lateral extrastriate^a	0.714	0.010	0.720	0.008	0.51	0.610	0.16
Medial striate^a	0.736	0.006	0.743	0.006	0.83	0.410	0.27
Medial inferior extrastriate^a	0.636	0.007	0.644	0.006	0.90	0.375	0.30
Medial superior extrastriate^a	0.676	0.008	0.684	0.007	0.80	0.430	0.26

ROI = region of interest; M = mean; SE = standard error; NAcc = nucleus accumbens; LPFC = lateral prefrontal cortex; sgACC = subgenual anterior cingulate cortex; mPFC = medial prefrontal cortex; ^a = visual network control regions; ^b = significant at p < 0.05.

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