Table 1 Parameter estimates for combined ion data sets for targeted effects (TE) and non-targeted effects (NTE) models for the dose response for fraction tumor prevalence.

From: Non-Targeted Effects Models Predict Significantly Higher Mars Mission Cancer Risk than Targeted Effects Models

Parameter

TE

NTE

P0

0.0290 ± 0.0035 (<10−4)

0.0268 ± 0.0035 (<10−4)

σ0, (μm2)

85.63 ± 17.13 (<10−4)

66.69 ± 40.68 (<10−4)

κ

713 ± 121 (<10−4)

750 ± 360 (<10−4)

σ0S, (μm2)

22.65 ± 20.38 (0.100)

16.44 ± 52.62 (0.389)

κS

469 ± 516 (0.405)

598 ± 1960 (0.761)

η0, (keV/μm)−1

—

0.00048 ± 0.00033 (<10−4)

η1, (keV/μm)−1

—

0.00281 ± 0.00320 (0.392)

Statistical Tests

 Adjusted R2

0.9999

0.9999

 AIC

−260.00

−264.65

 BIC

−249.79

−250.35

  1. Parameter fits and standard deviations (including p-values) are described using survival function parameters ms = 3 and D0 = 2.6 Gy, and tumor induction parameter m = 3. The model providing the optimal fit (lowest AIC or BIC values) is shown in bold-face.
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