Figure 3 | Scientific Reports

Figure 3

From: Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model

Figure 3

PhNR of normal and glaucomatous rat eyes. (A,B) Representative traces of the “a” wave, the “b” wave, and PhNR in a control eye (OS) and a glaucomatous eye (OD) at step 3 with the stimulus applied at 22.76 cd.s/m2–0.33 Hz. (C,D) Representative waves in a vehicle-treated glaucomatous eye (OS) and a PNU-282987-treated glaucomatous eye (OD) at the same step and stimulus used in (A,B). (E) Quantitative analysis of PhNR amplitude (n = 8). The amplitude was normalized to the amplitude in control retinas. ***p < 0.001 (one-way analysis of variance). The results in E are expressed as the mean ± SE. a, “a” wave; b, “b” wave; OHT, ocular hypertension; PhNR, photopic negative response.

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