Table 3 Associations of SIX1/SIX6 locus polymorphisms and circumpapillary retinal nerve fibre layer thickness in 32 sectors.
SNP | RNFL 01 | RNFL 02 | RNFL 03 | RNFL 04 | RNFL 05 | RNFL 06 | RNFL 07 | RNFL 08 | RNFL 09 | RNFL 10 | RNFL 11 | RNFL 12 | RNFL 13 | RNFL 14 | RNFL 15 | RNFL 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P* | P* | P* | P* | P* | P* | P* | P* | P* | P* | P* | P* | P* | P* | P* | P* | |
rs140399719 | 0.11 | 0.33 | 0.14 | 0.018 | 0.074 | 0.51 | 0.24 | 0.038 | 0.016 | 0.026 | 0.12 | 0.80 | 0.17 | 0.25 | 0.33 | 0.99 |
rs144039268 | 0.99 | 0.87 | 0.79 | 0.54 | 0.33 | 0.17 | 0.37 | 0.62 | 0.64 | 0.79 | 0.26 | 0.12 | 0.12 | 0.29 | 0.63 | 0.71 |
rs148908311 | 0.31 | 0.10 | 0.13 | 0.22 | 0.29 | 0.64 | 0.050 | 0.0011 | 0.022 | 0.57 | 0.81 | 0.29 | 0.17 | 0.22 | 0.68 | 0.72 |
rs10138913 | 0.12 | 0.060 | 0.15 | 0.21 | 0.45 | 0.21 | 0.79 | 0.058 | 0.057 | 0.76 | 0.12 | 0.19 | 0.34 | 0.68 | 0.096 | 0.012 |
rs33912345 | 0.14 | 0.067 | 0.08 | 0.054 | 0.089 | 0.026 | 0.57 | 0.050 | 0.039 | 0.54 | 0.25 | 0.84 | 0.70 | 0.087 | 0.011 | 0.0030 |
rs76172201 | 0.63 | 0.46 | 0.51 | 0.55 | 0.30 | 0.34 | 0.83 | 0.46 | 0.23 | 0.93 | 0.94 | 0.44 | 0.20 | 0.23 | 0.075 | 0.10 |
rs17097602 | 0.19 | 0.26 | 0.62 | 0.80 | 0.81 | 0.42 | 0.43 | 0.51 | 0.50 | 0.80 | 0.17 | 0.44 | 0.60 | 0.70 | 0.34 | 0.14 |
rs1955691 | 0.77 | 0.33 | 0.25 | 0.20 | 0.18 | 0.54 | 0.48 | 0.077 | 0.08 | 0.99 | 0.88 | 0.53 | 0.67 | 0.88 | 0.31 | 0.16 |
rs1010053 | 0.38 | 0.57 | 0.81 | 0.65 | 0.74 | 0.23 | 0.49 | 0.69 | 0.69 | 0.60 | 0.56 | 0.51 | 0.26 | 0.072 | 0.078 | 0.18 |
rs12587483 | 0.27 | 0.42 | 0.97 | 0.91 | 0.62 | 0.58 | 0.60 | 0.52 | 0.59 | 0.73 | 0.27 | 0.74 | 0.96 | 0.37 | 0.19 | 0.16 |
rs10133871 | 0.54 | 0.17 | 0.084 | 0.081 | 0.10 | 0.35 | 0.97 | 0.22 | 0.16 | 0.83 | 0.43 | 0.18 | 0.26 | 0.62 | 0.68 | 0.18 |
rs77636526 | 0.02 | 0.064 | 0.20 | 0.67 | 0.88 | 0.98 | 0.28 | 0.78 | 0.017 | 0.19 | 0.98 | 0.74 | 0.44 | 0.07 | 0.016 | 0.018 |
rs79319089 | 0.38 | 0.43 | 0.72 | 0.96 | 0.91 | 0.51 | 0.23 | 0.80 | 0.24 | 0.60 | 0.73 | 0.70 | 0.98 | 0.84 | 0.77 | 0.96 |
rs75320987 | 0.35 | 0.15 | 0.12 | 0.16 | 0.32 | 0.82 | 0.18 | 0.23 | 0.87 | 0.58 | 0.83 | 0.23 | 0.042 | 0.058 | 0.29 | 0.82 |
rs2057136 | 0.88 | 0.39 | 0.32 | 0.20 | 0.13 | 0.26 | 0.62 | 0.21 | 0.31 | 0.93 | 0.84 | 0.29 | 0.26 | 0.78 | 0.33 | 0.075 |
rs117183588 | 0.024 | 0.069 | 0.21 | 0.65 | 0.65 | 0.37 | 0.32 | 0.04 | 0.41 | 0.58 | 0.96 | 0.35 | 0.08 | 0.044 | 0.13 | 0.59 |
rs7153648 | 0.73 | 0.36 | 0.33 | 0.24 | 0.32 | 0.83 | 0.78 | 0.66 | 0.74 | 0.39 | 0.76 | 0.93 | 0.83 | 0.78 | 0.14 | 0.036 |
rs73309474 | 0.0098 | 0.04 | 0.07 | 0.18 | 0.31 | 0.17 | 0.58 | 0.11 | 0.86 | 0.89 | 0.98 | 0.59 | 0.28 | 0.13 | 0.16 | 0.45 |
rs143331462 | 0.96 | 0.81 | 0.35 | 0.16 | 0.15 | 0.31 | 0.49 | 0.52 | 0.38 | 0.64 | 0.29 | 0.34 | 0.38 | 0.69 | 0.71 | 0.63 |
rs7143029 | 0.087 | 0.036 | 0.020 | 0.030 | 0.044 | 0.11 | 0.76 | 0.58 | 0.80 | 0.56 | 0.68 | 0.73 | 0.86 | 0.87 | 0.50 | 0.16 |
rs12147345 | 0.070 | 0.029 | 0.018 | 0.023 | 0.034 | 0.11 | 0.75 | 0.67 | 0.88 | 0.48 | 0.77 | 0.79 | 0.86 | 0.89 | 0.45 | 0.14 |
rs12147346 | 0.34 | 0.11 | 0.070 | 0.073 | 0.082 | 0.27 | 0.67 | 0.85 | 0.94 | 0.44 | 0.80 | 0.67 | 0.78 | 0.96 | 0.39 | 0.18 |
rs10137383 | 0.21 | 0.14 | 0.085 | 0.20 | 0.19 | 0.33 | 0.56 | 0.55 | 0.88 | 0.74 | 0.48 | 0.59 | 0.62 | 0.81 | 0.52 | 0.98 |
rs12589826 | 0.28 | 0.090 | 0.055 | 0.056 | 0.074 | 0.27 | 0.60 | 0.73 | 0.81 | 0.36 | 0.84 | 0.68 | 0.79 | 0.98 | 0.39 | 0.18 |
rs2351179 | 0.50 | 0.97 | 0.96 | 0.76 | 0.82 | 0.95 | 0.94 | 0.55 | 0.34 | 0.50 | 0.45 | 0.42 | 0.44 | 0.60 | 0.28 | 0.20 |
rs61991690 | 0.44 | 0.80 | 0.90 | 0.70 | 0.54 | 0.76 | 0.60 | 0.98 | 0.75 | 0.63 | 0.13 | 0.63 | 0.86 | 0.80 | 0.42 | 0.64 |
SNP | RNFL 17 | RNFL 18 | RNFL 19 | RNFL 20 | RNFL 21 | RNFL 22 | RNFL 23 | RNFL 24 | RNFL 25 | RNFL 26 | RNFL 27 | RNFL 28 | RNFL 29 | RNFL 30 | RNFL 31 | RNFL 32 |
P * | P * | P * | P * | P * | P * | P * | P * | P * | P * | P * | P * | P * | P * | P * | P * | |
rs140399719 | 0.96 | 0.14 | 0.023 | 0.031 | 0.14 | 0.44 | 0.85 | 0.41 | 0.015 | 0.0031 | 0.18 | 0.99 | 0.38 | 0.12 | 0.89 | 0.13 |
rs144039268 | 0.82 | 0.58 | 0.65 | 0.67 | 0.45 | 0.64 | 0.64 | 0.26 | 0.23 | 0.56 | 0.68 | 0.33 | 0.26 | 0.28 | 0.41 | 0.74 |
rs148908311 | 0.82 | 0.60 | 0.24 | 0.21 | 0.39 | 0.99 | 0.49 | 0.31 | 0.94 | 0.28 | 0.20 | 0.48 | 0.80 | 0.95 | 0.98 | 0.66 |
rs10138913 | 0.025 | 0.37 | 0.86 | 0.47 | 0.54 | 0.94 | 0.70 | 0.60 | 0.018 | 2.9 × 10 −4 | 0.0035 | 0.14 | 0.10 | 0.088 | 0.081 | 0.20 |
rs33912345 | 0.019 | 0.64 | 0.55 | 0.79 | 0.77 | 0.43 | 0.23 | 0.61 | 0.07 | 8.1 × 10 −5 | 3.0 × 10 −5 | 0.0027 | 0.0027 | 0.012 | 0.031 | 0.14 |
rs76172201 | 0.10 | 0.20 | 0.17 | 0.29 | 0.44 | 0.70 | 0.72 | 0.78 | 0.65 | 0.73 | 0.99 | 0.81 | 0.52 | 0.27 | 0.15 | 0.22 |
rs17097602 | 0.47 | 0.98 | 0.77 | 0.63 | 0.50 | 0.85 | 0.91 | 0.46 | 0.034 | 0.0071 | 0.069 | 0.36 | 0.20 | 0.20 | 0.16 | 0.16 |
rs1955691 | 0.045 | 0.25 | 1.00 | 0.67 | 0.89 | 0.66 | 0.71 | 0.78 | 0.74 | 0.25 | 0.21 | 0.60 | 0.83 | 0.79 | 0.83 | 0.79 |
rs1010053 | 0.77 | 0.63 | 0.66 | 0.72 | 0.71 | 0.63 | 0.71 | 0.99 | 0.082 | 0.0016 | 0.0020 | 0.021 | 0.023 | 0.078 | 0.15 | 0.18 |
rs12587483 | 0.56 | 0.96 | 0.92 | 0.91 | 0.67 | 0.93 | 0.77 | 0.32 | 0.010 | 5.0 × 10 −4 | 0.014 | 0.26 | 0.24 | 0.27 | 0.23 | 0.17 |
rs10133871 | 0.05 | 0.32 | 0.88 | 0.50 | 0.96 | 0.77 | 0.46 | 0.67 | 0.86 | 0.70 | 0.68 | 0.80 | 0.64 | 0.55 | 0.59 | 0.98 |
rs77636526 | 0.12 | 0.18 | 0.16 | 0.10 | 0.02 | 0.070 | 0.41 | 0.70 | 0.87 | 0.93 | 0.34 | 0.048 | 0.043 | 0.038 | 0.023 | 0.029 |
rs79319089 | 0.99 | 0.69 | 0.52 | 0.36 | 0.24 | 0.45 | 0.31 | 0.82 | 0.92 | 0.33 | 0.28 | 0.56 | 0.79 | 0.37 | 0.19 | 0.21 |
rs75320987 | 0.37 | 0.94 | 0.084 | 0.03 | 0.18 | 0.62 | 0.82 | 0.85 | 0.38 | 0.047 | 0.044 | 0.27 | 0.58 | 0.61 | 0.73 | 0.87 |
rs2057136 | 0.016 | 0.18 | 0.65 | 0.21 | 0.40 | 0.86 | 1.00 | 0.72 | 0.20 | 0.036 | 0.14 | 0.79 | 0.86 | 0.71 | 0.84 | 0.66 |
rs117183588 | 0.41 | 0.18 | 0.36 | 0.62 | 0.27 | 0.49 | 0.78 | 0.85 | 0.58 | 0.34 | 0.46 | 0.48 | 0.74 | 0.96 | 0.51 | 0.074 |
rs7153648 | 0.0029 | 0.067 | 0.85 | 0.37 | 0.96 | 0.56 | 1.00 | 0.72 | 0.45 | 0.13 | 0.066 | 0.45 | 0.54 | 0.28 | 0.29 | 0.90 |
rs73309474 | 0.42 | 0.36 | 0.77 | 0.87 | 0.46 | 0.62 | 0.86 | 0.96 | 0.74 | 0.55 | 0.30 | 0.15 | 0.28 | 0.59 | 0.23 | 0.034 |
rs143331462 | 0.65 | 0.56 | 0.24 | 0.004 | 0.0084 | 0.04 | 0.029 | 0.061 | 0.67 | 0.27 | 0.062 | 0.13 | 0.069 | 0.13 | 0.38 | 0.80 |
rs7143029 | 0.070 | 0.51 | 0.96 | 0.80 | 0.31 | 0.23 | 0.34 | 0.61 | 0.45 | 0.025 | 0.0013 | 0.013 | 0.029 | 0.033 | 0.036 | 0.13 |
rs12147345 | 0.070 | 0.51 | 0.95 | 0.78 | 0.30 | 0.20 | 0.32 | 0.59 | 0.43 | 0.019 | 9.1 × 10 −4 | 0.010 | 0.024 | 0.028 | 0.030 | 0.11 |
rs12147346 | 0.072 | 0.42 | 0.92 | 0.79 | 0.30 | 0.29 | 0.56 | 0.75 | 0.51 | 0.033 | 0.0036 | 0.035 | 0.051 | 0.038 | 0.089 | 0.44 |
rs10137383 | 0.93 | 0.52 | 0.55 | 0.82 | 0.47 | 0.58 | 0.22 | 0.43 | 0.61 | 0.44 | 0.14 | 0.16 | 0.30 | 0.40 | 0.23 | 0.21 |
rs12589826 | 0.070 | 0.44 | 0.93 | 0.75 | 0.27 | 0.30 | 0.62 | 0.73 | 0.55 | 0.039 | 0.0042 | 0.032 | 0.036 | 0.022 | 0.057 | 0.36 |
rs2351179 | 0.094 | 0.37 | 0.61 | 0.26 | 0.051 | 0.10 | 0.17 | 0.18 | 0.49 | 0.51 | 0.99 | 0.55 | 0.37 | 0.28 | 0.74 | 0.32 |
rs61991690 | 0.41 | 0.90 | 0.76 | 0.95 | 0.49 | 0.50 | 0.77 | 0.80 | 0.53 | 0.16 | 0.21 | 0.34 | 0.36 | 0.42 | 0.35 | 0.28 |