Table 1 Integrins described as HSPC related.
From: Bone marrow niche-mimetics modulate HSPC function via integrin signaling
Integrin | CD | Gene Name | Ligands (in heterodimeres) | HSPC Function |
|---|---|---|---|---|
α4 | CD49d | ITGA4 | Fibronectin VCAM-1 | BM homing, BM engraftment, maintenance blocking leads to mobilization35, 63 |
α5 | CD49e | ITGA5 | Fibronectin Osteopontin | |
α6 | CD49f | ITGA6 | Laminin | Blocking leads to reduced BM homing66 |
αIIb | CD41 | ITGAIIb | Fibronectin | Early hematopoiesis, BM logement, regulation of progenitor number67,68,69 |
αV | CD51 | ITGAV | Fibronectin Vitronectin Tenascin | Maintenance37 |
β1 | CD29 | ITGB1 | Collagen Laminin Fibronectin Osteopontin | |
β3 | CD61 | ITGB3 | Fibronectin |