Figure 7 | Scientific Reports

Figure 7

From: Glucocorticoids ameliorate TGF-β1-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail/Slug signaling pathways

Figure 7

Hypothetical schema of the role of glucocorticoids in TGF-β1-induced EMT in airway epithelial cells and nasal ex vivo organ culture. GCs modulate EMT-related proteins; E-cadherin, α-SMA, vimentin and fibronectin by inhibiting the p38/ERK and Snail/Slug signaling pathways, resulting in restrained migration and invasion in the airway epithelium under EMT mediated by TGF-β1.

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