Figure 1

Relationship between gender and site of onset in C9orf72 repeat expansion carriers. Donut chart showing the site of symptom onset and age at onset among male and female C9orf72 carriers. Inner layer shows the proportion of males (52.6%) and females (47.4%) in the cohort. The middle layer shows the site of onset within males and females. The outer histogram layer shows the age distribution within each subset. The y-axis of this outer histogram represents the number of patients at each age, whereas the x-axis represents age at symptom onset ranging from 25 to 83 years of age. The graph was created using Circos (version 0.67, available at www.circos.ca) and FusionCharts (www.jsfiddle.net/fusioncharts/J7svz).