Figure 1 | Scientific Reports

Figure 1

From: Somatic Tumor Mutations Detected by Targeted Next Generation Sequencing in Minute Amounts of Serum-Derived Cell-Free DNA

Figure 1

Substitution spectra of variants called relative to the reference genome in DNA derived from formalin fixed paraffin embedded (FFPE) matched normal specimens. (A) The contribution of the six possible base substitutions (C > A in blue, C > G in black, C > T in red, T > A in grey, T > C in green and T > G in pink) are depicted for each of six patients (P1 to P6) relative to the total variants in that sample. The total number of detected variants is depicted at the right end of the bars. (B) A threshold removing variants with variant frequencies below 35% was applied to FFPE preserved matched normal specimens. The resulting substitution spectra (as in A) are depicted for each of the six patients (P1 to P6).

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