Figure 2

Defining somatic origin of variants using matched normal DNA (MN) or virtual normal genomes (VN) as reference. Annotation of variants detected in the primary tumors of the four patients of who matched normal was accessible (P1, P2, P3 and P6) are depicted relative to the total variants in that sample. In here, variants absent from both the VN and MN in black, variants present in both VN and MN in blue, variants absent in the VN but present in the MN in grey, and variants present in the VN but absent from the MN in yellow. The total number of detected variants is depicted at the right end of the bars.