Figure 3 | Scientific Reports

Figure 3

From: A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme

Figure 3The alternative text for this image may have been generated using AI.

Neuron rich frontal cortex (FC) showed higher A-to-I editing in mature miRNAs than the corresponding corpus callosum (CC) of the same individuals. (A) FC showed higher A-to-I editing than CC of the same individuals (two-tailed t-test; p = 0.015). (B) Real-time PCR was done and delta Ct was plotted, ADAR2 (and not ADAR1, two-tailed t-test; p = 0.63) showed significant upregulation in FC compared to CC samples (two-tailed t-test; p = 0.008). B2M was used to normalize expression in all samples.

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