Table 2 Correlation coefficient (r) between the 22 nephrobiomarkers and the studied patients’ parameters.
Biomarkers | Kidney function markers | Glycemic marker | Lipid markers | Clinical markers | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ACR | eGFR | HOMA_IR | HbA1C | FPG | Triglycerides | Cholesterol | LDL | SBP | Weight | |||||||||||
r | p | r | p | r | p | r | p | r | p | r | p | r | p | r | p | r | p | r | p | |
Transferrin (U) ng/ml | 0.703 | <0.001 | −0.362 | <0.001 | 0.18 | 0.001 | 0.169 | <0.001 | 0.220 | <0.001 | 0.245 | <0.001 | 0.069 | 0.138 | −0.024 | 0.611 | 0.312 | <0.001 | 0.062 | 0.182 |
Osteopontin pg/ml | 0.607 | <0.001 | −0.326 | <0.001 | 0.174 | 0.002 | 0.212 | <0.001 | 0.158 | 0.001 | 0.134 | 0.005 | 0.001 | 0.982 | −0.079 | 0.098 | 0.282 | <0.001 | −0.013 | 0.783 |
RBP (U) ng/ml | 0.229 | <0.001 | −0.142 | 0.003 | 0.002 | 0.972 | 0.079 | 0.096 | 0.025 | 0.595 | 0.005 | 0.917 | 0.009 | 0.853 | −0.016 | 0.739 | 0.048 | 0.312 | 0.129 | 0.006 |
Interleukin−18 pg/ml | 0.395 | <0.001 | −0.420 | <0.001 | 0.132 | 0.018 | 0.187 | <0.001 | 0.124 | 0.008 | 0.138 | 0.003 | 0.033 | 0.485 | 0.053 | 0.261 | 0.106 | 0.024 | 0.118 | 0.012 |
Cystatin-C ng/ml | 0.332 | <0.001 | −0.492 | <0.001 | −0.023 | 0.682 | 0.059 | 0.219 | −0.121 | 0.011 | 0.087 | 0.068 | −0.038 | 0.431 | −0.067 | 0.165 | 0.127 | 0.007 | 0.012 | 0.806 |
Resistin g/ml | 0.339 | <0.001 | −0.344 | <0.001 | 0.085 | 0.142 | 0.063 | 0.197 | −0.037 | 0.444 | 0.057 | 0.24 | −0.016 | 0.746 | −0.125 | 0.01 | 0.106 | 0.029 | 0.077 | 0.113 |
YKL-40 (P) ng/ml | 0.188 | <0.001 | −0.161 | 0.001 | 0.078 | 0.165 | 0.179 | <0.001 | 0.049 | 0.305 | 0.092 | 0.053 | −0.005 | 0.915 | −0.051 | 0.288 | 0.115 | 0.015 | 0.086 | 0.070 |
TNF-α pg/ml | 0.279 | <0.001 | −0.321 | <0.001 | 0.283 | <0.001 | 0.201 | <0.001 | 0.061 | 0.193 | 0.14 | 0.003 | 0.037 | 0.424 | 0.05 | 0.287 | 0.137 | 0.003 | 0.009 | 0.849 |
Interleukin-6 pg/ml | 0.226 | <0.001 | −0.198 | <0.001 | 0.072 | 0.196 | 0.192 | <0.001 | −0.040 | 0.400 | −0.059 | 0.212 | −0.069 | 0.143 | −0.063 | 0.185 | 0.166 | <0.001 | 0.201 | <0.001 |
VCAM-1 ng/ml | 0.152 | 0.001 | −0.194 | <0.001 | 0.161 | 0.003 | 0.124 | 0.008 | 0.158 | 0.001 | 0.035 | 0.459 | −0.014 | 0.767 | −0.035 | 0.454 | 0.118 | 0.011 | 0.105 | 0.024 |
Adiponectin ng/ml | 0.139 | 0.004 | −0.122 | 0.013 | −0.158 | 0.006 | −0.087 | 0.071 | −0.139 | 0.004 | −0.196 | <0.001 | 0.11 | 0.022 | 0.049 | 0.307 | −0.013 | 0.793 | −0.053 | 0.266 |
NGAL ng/ml | 0.210 | <0.001 | −0.213 | <0.001 | 0.120 | 0.029 | 0.093 | 0.045 | 0.012 | 0.792 | 0.080 | 0.084 | 0.012 | 0.797 | 0.014 | 0.758 | 0.102 | 0.027 | 0.036 | 0.437 |
Interleukin-1α pg/ml | 0.201 | <0.001 | −0.224 | <0.001 | −0.09 | 0.135 | −0.005 | 0.918 | 0.012 | 0.818 | 0.019 | 0.714 | 0.051 | 0.312 | −0.03 | 0.551 | −0.028 | 0.586 | 0.078 | 0.123 |
E-selectin ng/ml | 0.002 | 0.965 | −0.065 | 0.183 | 0.182 | 0.001 | 0.14 | 0.003 | 0.137 | 0.004 | 0.091 | 0.053 | 0 | 0.996 | 0.042 | 0.376 | 0.062 | 0.186 | 0.205 | <0.001 |
CRP ng/ml | 0.04 | 0.414 | −0.032 | 0.521 | 0.12 | 0.038 | 0.228 | <0.001 | 0.041 | 0.406 | 0.015 | 0.754 | −0.047 | 0.336 | −0.011 | 0.818 | 0.088 | 0.071 | 0.160 | 0.001 |
ICAM-1 ng/ml | 0.017 | 0.724 | −0.022 | 0.650 | 0.139 | 0.012 | 0.147 | 0.002 | 0.100 | 0.034 | 0.01 | 0.838 | 0.027 | 0.563 | 0.067 | 0.153 | 0.034 | 0.47 | 0.081 | 0.086 |
Leptin ng/ml | 0.154 | 0.002 | −0.128 | 0.011 | 0.106 | 0.066 | 0.127 | 0.009 | −0.042 | 0.387 | −0.034 | 0.488 | 0.143 | 0.003 | 0.07 | 0.151 | 0.095 | 0.051 | 0.169 | 0.001 |
MCP-1 pg/ml | −0.148 | 0.002 | −0.035 | 0.475 | −0.056 | 0.317 | −0.143 | 0.002 | −0.154 | 0.001 | −0.058 | 0.22 | −0.001 | 0.986 | 0.029 | 0.537 | −0.054 | 0.254 | 0.054 | 0.247 |
P-selectin ng/ml | −0.092 | 0.049 | −0.022 | 0.645 | 0.122 | 0.028 | 0.079 | 0.091 | 0.127 | 0.007 | 0.023 | 0.625 | 0.079 | 0.09 | 0.102 | 0.029 | −0.042 | 0.366 | 0.099 | 0.034 |
L-selectin ng/ml | −0.142 | 0.002 | 0.057 | 0.237 | −0.039 | 0.481 | −0.023 | 0.63 | 0.002 | 0.971 | −0.079 | 0.092 | 0.022 | 0.632 | 0.002 | 0.968 | −0.05 | 0.285 | 0.096 | 0.039 |
PAI-1 ng/ml | −0.165 | <0.001 | 0.140 | 0.004 | −0.032 | 0.563 | −0.042 | 0.372 | −0.151 | 0.001 | 0.067 | 0.154 | 0.037 | 0.439 | 0.107 | 0.024 | −0.085 | 0.073 | −0.033 | 0.480 |
Fetuin-A µg/ml | −0.291 | <0.001 | 0.061 | 0.204 | −0.159 | 0.004 | −0.141 | 0.002 | −0.096 | 0.038 | −0.079 | 0.087 | 0.015 | 0.752 | 0.056 | 0.23 | −0.182 | <0.001 | −0.041 | 0.375 |