Figure 4
UTP-attenuated cyclin D1 and ppRb through P2Y6-mediated Ca2+ and β-catenin signaling. (a and d) UTP (20 µM), UDP (50 µM), spiperone (10 µM) and CPA (10 µM) repressed cyclin D1 and ppRb (Ser807/811&Ser780) in MKN-45 and SGC-7901 cells. (b and e) Over-expression β-catenin rescued UTP-repressed cyclin D1 and ppRb (Ser807/811&Ser780) in MKN-45 and SGC-7901 cells. (c and f) Over-expression β-catenin rescued spiperone-repressed cyclin D1 and ppRb (Ser807/811 & Ser780) in MKN-45 and SGC-7901 cells.
