Figure 5
Nucleotides-induced Ca2+ signaling through activation of P2Y6 receptors in gastric cancer cells. (a,b) Time courses of [Ca2+]cyt changes induced by UDP (50 µM) and UTP (20 µM) in MKN-45 cells (a) and SGC-7901 cells (b). (c,d) Effect of MRS2578 (10 µM) on UDP-induced [Ca2+]cyt in MKN-45 cells (c) and SGC-7901 cells (d). (e,f) Effect of MRS2578 (10 µM) on UTP-induced [Ca2+]cyt in MKN-45 cells (e) and SGC-7901 cells (f). (g,h) Summary data showing the [Ca2+]cyt changes induced by nucleotides and effect of MRS2578 on nucleotides-induced [Ca2+]cyt in MKN-45 cells (g) and SGC-7901 cells (h). Data are shown as the mean ± SD of 40–50 cells for each group, ***P < 0.001 vs control.
