Figure 6

UTP-induced Ca²⁺ signaling through SOC mechanism in gastric cancer cells. (a) Time courses of [Ca²⁺]_cyt changes induced by UTP (20 µM) in the absence or the presence of extracellular Ca²⁺ in MKN-45 cells. (b,c) Effect of U73122 (10 µM) or 2-APB (50 µM) on UTP-induced [Ca²⁺]_cyt changes in MKN-45 cells. (d,e) Summary data showing the effect of U73122 or 2-APB on UTP-induced [Ca²⁺]_cyt in MKN-45 cells (d) and SGC-7901 cells (e). (f–h) Time courses of [Ca²⁺]_cyt changes induced by UTP, siperone (10 µM) or CPA (10 µM) in the absence of extracellular Ca²⁺ in MKN-45 cells. (i) Summary data showing UTP, siperone or CPA induced [Ca²⁺]_cyt in the absence of extracellular Ca²⁺. (j,k) time courses of [Ca²⁺]_cyt changes induced by CPA and UTP, or siperone and UTP in the absence of extracellular Ca²⁺ in MKN-45 cells. (l,m) Summary data showing CPA and UTP, or siperone and UTP induced [Ca²⁺]_cyt in the absence of extracellular Ca²⁺. Data are shown as the mean ± SD of 40–50 cells for each group, ***P < 0.001 vs control.