Figure 8
P2Y6 receptors-mediated suppression of gastric tumor growth in mice. (a–h) Nude mice subcutaneously xenografted in their armpits of SGC-7901 cell. (a–d) Both UTP (50 µM) and UDP (100 µM, the left side) inhibited tumor weight compared to PBS (the right side). (e–h) MRS2578 (10 µM, the right side) rescued both UTP and UDP (the left side)-suppressed tumor weight. (i–k) Nude mice subcutaneously xenografted in their armpits of SGC-7901 cell pretreated with stably transfecting P2Y6 receptors-shRNA (the right side) and P2Y6 receptors-NC lentiviruses (the left side). (i) Small animals fluorescence imaging showed knockdown of P2Y6 receptors increased tumor weight. (j) White light photographs. (k) Summary data of the tumor weight in knockdown of P2Y6 receptors and NC-treated groups. *p < 0.05, ***p < 0.001, n = 5.
