Figure 9
A proposed model for P2Y6-mediated suppression of gastric tumorigenesis through SOCE/Ca2+/β-catenin signaling pathways. Activation of P2Y6 receptors induces IP3 production by PLC. IP3 activates IP3R on the ER to induce intracellular Ca2+ release and extracellular Ca2+ influx via the SOC. Finally Ca2+ inhibits β-catenin and suppresses proliferation of GC cells. Overexp: over-expression of β-catenin.
