Table 1 Summary of incus and stapes defects in mice deficient for Jag1, Notch2, and Twist1.
From: Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear
Genotype | N | Incus | Stapes | N | Retrotympanic process | |
|---|---|---|---|---|---|---|
ectopic posterior medial process | ectopic anterior medial process | small or no lumen | broken | |||
Wild type | 18 | 3 (16.7%) | 0 (0%) | 0 (0%) | 23 | 1 (4%) |
Jag1 f/+ | 9 | 0 (0%) | 0 (0%) | 0 (0%) | N.D. | — |
Wnt1-Cre; Jag1 f/+ | 9 | 0 (0%) | 0 (0%) | 0 (0%) | N.D. | — |
Wnt1-Cre; Jag1 f/f | 8 | 1 (12.5%) | 0 (0%) | 8 (100%)d | N.D. | — |
Notch2 f/+ | 5 | 0 (0%) | 0 (0%) | 0 (0%) | N.D. | — |
Wnt1-Cre; Notch2 f/+ | 7 | 0 (0%) | 0 (0%) | 0 (0%) | N.D. | — |
Wnt1-Cre; Notch2 f/f | 8 | 0 (0%) | 1 (12.5%) | 8 (100%)e | N.D. | — |
Jag1 +/− | 20 | 15 (75%)a | 0 (0%) | 5 (25%)f | 15 | 0 (0%) |
Twist1 +/− | 16 | 0 (0%) | 6 (38%)b | 0 (0%) | 18 | 2 (11%) |
Jag1 +/−; Twist1 +/− | 13 | 0 (0%) | 9 (69%)c | 1 (8%) | 22 | 15 (68%)g |
