Figure 6

Survival analysis using Kaplan-Meier survival curve and X-tile plot. The cases with high levels of circulating miR-214 showed significantly shorter survival time in the cases of adenocarcinoma and the non-epithelial tumours without osteosarcoma. The cases with high levels of circulating miR-126 showed significantly shorter survival times in the cases of epithelial tumours, adenocarcinoma, and melanoma. (a) Survival times between the cases with high- and low-circulating miR-214 and -126 in the group including all types of tumours. (b) Survival times between the cases with high- and low-circulating miR-214 and -126 levels for the epithelial and the non-epithelial tumours. (c) Comparison of the levels of circulating miR-214 between osteosarcomas (OSA) and the other non-epithelial tumours. (d) Survival times between the cases with high- and low-circulating miR-214 and -126 levels for the non-epithelial tumours excluding osteosarcomas. (e) Survival times between the cases with high- and low-circulating miR-214 and -126 levels for adenocarcinomas and melanomas. All MST values (days) were calculated from the analysis using Kaplan-Meier survival curves. The optimal cut-offs to determine the groups of high- and low-miRNA levels were calculated by use of the X-tile plot. The hazard ratios and P-values were calculated by using the Log-rank test.