Table 1 Melting temperatures (Tm, °C) of HSV-1 G4 folding sequences measured by CD in the absence or presence (100 mM) of KCl. Each sequence (4 μM) was analyzed in the absence or presence of c-exNDI (16 μM). nd stands for “not detected”.

From: A core extended naphtalene diimide G-quadruplex ligand potently inhibits herpes simplex virus 1 replication

Melting temperature

G4 sequence

KCl 0 (°C)

ΔTm (°C)

KCl 100 mM (°C)

ΔTm (°C)

c-exNDI

—

+

 

—

+

 

gp054a

nd

nd

—

64.3 ± 0.84

79.5 ± 0.61

15.2

un2

50.6 ± 0.53

56.8 ± 0.62

6.2

>90

>90

—

un3

nd

nd

—

65.1 ± 3.03

>90

>24.9

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