Table 2 Central tendency (mean and median) and heterogeneity (SD, kurtosis, skewness) MRI parameters in 39 HCC lesions and liver parenchyma in 32 patients.

From: Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

 

Mean

Median

SD

Kurtosis

Skewness

Liver

HCC

P *

Liver

HCC

P *

Liver

HCC

P *

Liver

HCC

P *

Liver

HCC

P *

Fa

49 ± 45

247 ± 240

<0.001

47 ± 45

241 ± 250

<0.001

16.3 ± 13.0

83.0 ± 66.7

<0.001

4.3 ± 1.8

5.5 ± 6.0

0.754

0.76 ± 0.66

0.44 ± 1.34

0.232

Fp

145 ± 123

112 ± 156

0.048

146 ± 126

103 ± 166

0.010

39.9 ± 32.5

78.6 ± 78.6

0.020

6.3 ± 14.0

64.1 ± 183.6

0.005

0.54 ± 1.57

4.00 ± 6.41

<0.001

Ft

193 ± 122

358 ± 337

0.023

193 ± 125

342 ± 350

0.092

43.7 ± 36.2

144.3 ± 126.3

<0.001

4.5 ± 3.1

17.1 ± 54.9

0.969

0.62 ± 0.76

1.14 ± 3.11

0.984

ART

33.9 ± 27.9

78.9 ± 21.5

<0.001

33.0 ± 29.1

80.3 ± 24.2

<0.001

9.7 ± 5.1

13.1 ± 9.0

0.055

7.6 ± 10.5

30.1 ± 61.8

0.256

0.68 ± 1.71

−2.49 ± 4.37

<0.001

MTT

20.3 ± 12.3

21.2 ± 15.8

0.724

19.7 ± 12.1

18.8 ± 16.3

0.667

4.2 ± 2.9

10.9 ± 7.3

<0.001

5.2 ± 4.8

9.1 ± 17.4

0.938

0.90 ± 0.87

1.54 ± 2.06

0.337

DV

37.4 ± 22.7

34.6 ± 24.7

0.695

36.8 ± 22.8

34.0 ± 26.0

0.710

4.9 ± 3.4

9.9 ± 5.7

<0.001

3.7 ± 1.7

5.5 ± 10.8

0.240

0.58 ± 0.61

0.70 ± 1.59

0.468

R2* pre O2

55.3 ± 34.4

34.5 ± 15.1

<0.001

54.7 ± 34.8

33.1 ± 15.0

<0.001

7.6 ± 7.5

7.6 ± 5.2

0.681

4.0 ± 2.9

5.2 ± 4.3

0.433

0.35 ± 0.89

0.92 ± 1.09

0.055

R2* post O2

51.8 ± 30.8

33.7 ± 14.5

<0.001

51.5 ± 31.4

32.7 ± 14.6

<0.001

8.3 ± 10.7

8.0 ± 4.7

0.347

3.5 ± 1.8

4.0 ± 2.7

0.984

0.15 ± 0.64

0.72 ± 0.81

0.011

ΔR2*

−3.47 ± 10.0

−0.78 ± 8.74

0.281

−3.12 ± 8.8

−0.86 ± 7.48

0.264

8.8 ± 9.5

8.6 ± 5.2

0.638

3.9 ± 2.0

4.7 ±  ± 3.6

0.830

−0.18 ± 0.72

−0.16 ± 0.94

0.799

R1 pre O2

1.76 ± 0.47

1.67 ± 0.94

0.052

1.76 ± 0.46

1.58 ± 0.73

0.033

0.12 ± 0.14

0.75 ± 3.31

0.008

3.7 ± 2.2

8.1 ± 17.7

0.531

−0.12 ± 0.76

0.72 ± 2.07

0.012

R1 post O2

1.87 ± 0.73

1.90 ± 1.79

0.027

1.77 ± 0.63

1.54 ± 0.61

0.026

2.26 ± 7.73

1.44 ± 5.48

0.422

71.4 ± 257.6

16.5 ± 34.5

0.327

2.13 ± 8.07

1.41 ± 2.76

0.153

ΔR1

0.11 ± 0.45

0.23 ± 1.15

0.176

0.01 ± 0.24

−0.05 ± 0.25

0.829

2.26 ± 7.73

1.06 ± 3.46

0.196

72.2 ± 257.4

17.6 ± 44.6

0.814

2.14 ± 8.08

1.50 ± 3.03

0.112

ADC

1.31 ± 0.58

1.43 ± 0.68

<0.001

1.31 ± 0.58

1.41 ± 0.70

<0.001

0.2 ± 0.1

0.3 ± 0.2

0.142

3.8 ± 2.2

4.0 ± 6.4

0.030

0.10 ± 0.79

0.33 ± 0.90

0.337

  1. *P-values from Wilcoxon signed rank tests. Significant P-values are bolded. ADC = apparent diffusion coefficient (10−3 mm2/s), ART = arterial fraction (%), DV = distribution volume (%), Fa = arterial flow (ml/100 g/min), Fp = portal flow (ml/100 g/min), Ft = total flow (ml/100 g/min), MTT = mean transit time (s), R1 = longitudinal relaxation rate (s−1), R2* = transverse relaxation rate (s−1).
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