Figure 1 | Scientific Reports

Figure 1

From: Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype

Figure 1

Transcription factor modules. (a) - Graphical representation of the regulons of the 17 Transcription Factors in the NACT dataset Inferred by ARACNE algorithm. Regulons: 1 – SNAI2, TWIST1, PRRX1, BNC2, TBX5, 2 – SCML4, ZNF831, SP140, IKZF3, 3 – ID4, 4 – HOXA5, 5 – ZNF503, 6 – TSC22D1. 7 – HOXB3, 8 – CREB3L1, 9 – GATA6. The Regulon of FOXF2 has 32 genes, these genes are shared by the regulons of SNAI2, TWIST1, PRRX1, BNC2, TBX5, ID4 and HOXA5 and are not identifiable in the figure. Green triangles represent genes, the lines linking them represent a relationship between the expression of them. (b) - Mesenchymal Transcription Module and (c) - Immune Response Transcription Module. Master regulators of the bCSC phenotype inferred by MRA-FET in the bCS/CC dataset.

Back to article page