Figure 6
The hypothalamic-pituitary-GH axis. (a) Hypothalamic relative orexin mRNA; (b) Hypothalamic relative GHRH mRNA; (c) hypothalamic relative somatostatin relative mRNA; (d) Pulsatile GH concentrations in two representative C and two AO animals; (e) average baseline value of GH; (f) Total GH concentration; (g) Average GH concentration; (h) Liver IGF-1 relative mRNA; (i) Serum IGF-1; (j) Liver IGFBP-1 relative mRNA; (k) Liver relative IGFBP-3 mRNA; GH – growth hormone; GHRH – growth hormone releasing hormone; IGF-1 – insulin-like growth factor 1; IGFBP 1 and 3 – IGF-binding protein 1 and 3. Error bars are s.d. *p < 0.05, **p < 0.01, ***p < 0.0001 difference between control group (C, blue color) and obstructive group (AO, green color) or between C and OR obstruction removal (OR, green color). # p < 0.05 difference between AO and OR. Statistical differences were determined by unpaired 2-tailed t test.
