Figure 7
From: A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation
Knockdown ECRG4 affects the expression of genes implicated in inflammation and cardiac remodeling. Knockdown ECRG4 was performed as described in materials and methods and gene expression normalized to GAPDH was expressed as relative expression of the knockdown using Luc-siRNA, which was arbitrarily set as 1. Knockdown ECRG4 significantly increased the expression of IL1a, IL6, and MCP1 (A, P < 0.05 in all) but not that of NF-kb p50 (ns, non-significant) (A), inhibited the expression of Gja1 (B, P < 0.05) and activated the expression of MMP3, s100a1 and s100a8 (B, P < 0.05 in all). Data were presented as “Mean ± SD”, and the experiments were performed in triplicate and repeated three times.
