Table 1 The intracellular metabolites of Saccharomyces cerevisiae identified by GC-MS that differ between the control group and the TCBPA-treated groups.

From: The Toxic Effects of Tetrachlorobisphenol A in Saccharomyces cerevisiae Cells via Metabolic Interference

retention time

Metabolite

TCBPA content (μM)

0

25

50

100

6.592

D-Lactic acid

31.12 ± 4.22

37.59 ± 2.39

34.29 ± 2.03

56.14 ± 4.99**

7.971

L-Alanine

22.22 ± 7.17

80.65 ± 7.25***

46.42 ± 12.76

74.03 ± 6.69***

11.061

Phosphoric acid

4.20 ± 0.82

0*

0**

0**

12.315

L-Valine

9.85 ± 2.62

37.01 ± 2.67***

17.21 ± 5.94

30.49 ± 2.74***

13.263

Serine

2.56 ± 0.70

0*

0*

0*

13.611

Leucine

12.61 ± 2.75

61.97 ± 4.25***

31.27 ± 9.82

52.83 ± 4.37***

13.756

Glycerol

38.32 ± 3.10

69.85 ± 4.48***

52.27 ± 5.00*

72.04 ± 2.78***

14.008

L-Isoleucine

11.13 ± 2.53

40.84 ± 3.26***

12.75 ± 8.03

28.47 ± 4.60**

14.199

Glycine

3.59 ± 1.18

5.25 ± 1.77

8.73 ± 1.75*

10.12 ± 2.03*

14.3

Succinic acid

4.72 ± 0.76

3.57 ± 1.67

0**

0**

15.457

L-threonine

9.34 ± 2.54

22.79 ± 2.05**

4.89 ± 4.89

13.54 ± 3.70

16.889

L-Proline

25.02 ± 5.65

76.25 ± 6.40***

15.67 ± 15.67

27.85 ± 11.85

18.293

Glutamic acid

2.61 ± 0.87

0*

0*

0*

18.987

Phosphoric acid

4.18 ± 1.47

0*

0*

0*

19.252

Glucofuranoside

5.09 ± 3.63

438.34 ± 49.83***

319.60 ± 86.23*

342.80 ± 56.12**

19.47

D-Fructopyranose

2.13 ± 0.74

16.83 ± 1.18***

15.10 ± 1.45***

17.77 ± 0.58***

19.578

D-Talopyranose

2.07 ± 2.07

512.15 ± 50.97***

276.10 ± 81.90*

323.98 ± 57.16**

19.61

D-Allofuranose

12.21 ± 3.24

728.37 ± 70.44***

517.09 ± 135.92*

521.96 ± 91.76**

19.836

Tyrosine

2.68 ± 1.03

7.71 ± 1.69*

0*

0*

19.973

D-Galactopyranose

53.63 ± 4.99

541.25 ± 51.57***

652.36 ± 30.51***

818.21 ± 61.67***

20.039

D-Talopyranose

5.98 ± 1.88

508.52 ± 35.71***

378.44 ± 80.32**

405.68 ± 54.30**

20.517

D-Allopyranose

90.93 ± 8.08

644.93 ± 74.87**

740.30 ± 28.26***

1014.02 ± 81.57***

21.388

Mannobiose

2.60 ± 1.73

37.53 ± 11.81*

17.97 ± 3.69**

16.90 ± 1.50***

23.282

Acetic acid

3.19 ± 1.80

9.97 ± 2.28*

20.01 ± 4.29**

15.82 ± 1.51***

23.642

Cholesterol

12.77 ± 1.68

33.98 ± 9.73

58.74 ± 9.34**

51.53 ± 9.36**

23.902

Hexadecanoic acid

19.66 ± 3.41

72.24 ± 16.17*

111.20 ± 11.04***

105.21 ± 17.22**

24.109

Sucrose

3.28 ± 1.16

15.93 ± 3.50**

23.19 ± 5.63**

22.14 ± 2.61***

24.233

Palatinose

4.03 ± 1.08

37.59 ± 2.94***

62.31 ± 5.32***

54.43 ± 5.74***

24.876

Octadecanoic acid

22.33 ± 4.90

80.40 ± 10.80**

126.02 ± 11.82***

116.79 ± 11.05***

24.989

Trehalose

6.16 ± 1.43

37.94 ± 1.80***

90.76 ± 11.13**

109.02 ± 20.31**

27.423

Unknown

6.68 ± 1.27

31.02 ± 3.69**

87.42 ± 14.58**

61.94 ± 11.79**

  1. The VIP scores of all listed metabolites are greater than 1. The data represents the relative peak intensity and are presented as the mean ± SEM. *P < 0.05 compared with the control. **P < 0.01 compared with the control. ***P < 0.001 compared with the control.
Back to article page