Figure 1
From: RNA-sequencing Identifies Novel Pathways in Sarcoidosis Monocytes
Differential gene expression and pathways between control and sarcoidosis monocytes. (a) Scatter plot of the entire gene expression data (healthy versus sarcoidosis monocytes) analyzed by DEseq2 analysis tool, where the log2-fold change (>0.5) of each gene is plotted against the total number of counts recorded for that gene. DE genes (FDR < 5%) are highlighted in red. (b) Significant pathways modulated in sarcoidosis monocytes as compared to healthy controls. Pathway analysis was done on the DE genes (log2-fold change > 0.6 and FDR < 5%) using iPathwayGuide analysis tool that uses two types of evidence: the over-representation on the horizontal axis (pORA) and the perturbation on the vertical axis (pAcc). Significant pathways (FDR < 5%) are shown in red, whereas non-significant are in black. The size of the circle is proportional to the number of genes in that pathway.
