Figure 4
From: RNA-sequencing Identifies Novel Pathways in Sarcoidosis Monocytes
Upregulation of genes involved in lysosomal pathway in sarcoidosis monocytes. Graphic illustration of pathway analysis of DE (log2-fold change with FDR < 0.05) genes related to lysosome in sarcoidosis monocytes. The pathway diagram is overlaid with the computed perturbation of each gene. The perturbation accounts both for the gene’s measured fold changes and for accumulated perturbation propagated from any upstream genes (accumulation). The color intensity corresponds to the level of upregulation (red) or downregulation (blue) of the DE genes in sarcoidosis monocytes versus healthy monocytes. Note: Various genes involved in lysosomal membrane proteins and acid hydrolases were upregulated except LAPTM4B gene which was downregulated.
