Figure 1
From: Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins
Sequence alignment and phylogenetic tree of aminergic toxins. (A) Sequence alignment of the aminergic toxin family. Color display is settled in order to emphasize amino acid conservation along all toxins. (B) Maximum likelihood tree and associated function of the aminergic toxins. The best evolutionary model established by MEGA5 was the Dayhoff model using a discrete Gamma distribution (+G). Bootstraps value higher than 50% are shown. MTLP-1 and 2 were used as out-group. Toxin’s functions are also illustrated by circles identifying the receptor targeted (color) and the corresponding Ki value (circle size), as described in the right legend, at the right side of each toxin name.
