Table 2 Affinity constant (pKi ± SEM) of MT3, ρ-Da1b and AncTx5 toxins for muscarinic (M1, M4), adrenergic (α1A, α1B, α1D, α2A, α2CB, α2C) and dopaminergic (D3) receptors.
From: Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins
Toxin Receptor subtype | MT3a | AncTx5 | ρ-Da1ba |
|---|---|---|---|
α1A | 8.84 | <6 | <6 |
α1B | 7.68 | <6 | <6 |
α1D | 7.88 | <6 | <6 |
α2A | 8.51 | 8,33 ± 0,04 | 7.85 |
α2B | <6 | 8,11 ± 0,07 | 6.66 |
α2C | 8.82 | 8,46 ± 0,01 | 7.44 |
M1 | 6.22 | <6 | <6 |
M4 | 9.08 | 6,81 ± 0,15 | <6 |
D3 | <6 | 6,81 ± 0,09 | 6.12 |
