Figure 1
Effect of STZ, celecoxib and gingerol on the mean escape latency in the Morris water maze. Animals were divided into 5 groups. Group 1 received a single ICV dose of saline; then, after 2 weeks, animals were intraperitoneally injected with saline for seven days. Group 2 received a single injection of STZ (3 mg/kg, i.c.v.), and then, after 2 weeks, they were intraperitoneally injected with saline for 7 days. Group A was injected with STZ (3 mg/kg, i.c.v.) once, and after 2 weeks, they were injected with celecoxib (30 mg/kg, i.p.) for 7 days. Group B received a single injection of STZ (3 mg/kg, i.c.v.), and after 2 weeks, they were injected with gingerol (10 mg/kg/day, i.p.) for 7 days. Group C was injected with STZ (3 mg/kg, i.c.v.) once, and after 2 weeks, they were injected with gingerol (20 mg/kg/day, i.p.) for 7 days. Animals from groups A, B, and C were subjected to the behavioral tests after the 3rd week of injections. Each result represents the mean value for 10 mice ± SE of the mean. Statistical analysis was carried out by one-way ANOVA followed by the Tukey-Kramer multiple comparison test with the aid of GraphPad Prism Software version 5. ***Significantly different from the normal group P < 0.001. ++Significantly different from the STZ group P < 0.01. +++Significantly different from the STZ group P < 0.001.
