Figure 1 | Scientific Reports

Figure 1

From: Exogenous interleukin 37 ameliorates atherosclerosis via inducing the Treg response in ApoE-deficient mice

Figure 1

Over-expression of IL-37 in human atherosclerotic plaques. (A) Normal human anterior tibial artery stained with hematoxylin-eosin. (B) Human atherosclerotic plaque. (C) Little IL-37 expression in ECs and VSMCs in normal artery (indicated by arrowheads). (D) Abundant IL-37 expression in foam cells in atherosclerotic plaque. D through F, IL-37 expression (D) in macrophages identified by anti-CD68 antibody (E) and VSMCs identified by anti-α-SMA antibody (F). IL-37 expression (G) in T lymphocytes identified by anti-CD3 antibody (H). (I) Results of statistical analysis of IL-37 expression in normal arteries and atherosclerotic plaques. Values are presented as the means ± SEM, n = 8. Black bar = 200μm. **p < 0.01.

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