Figure 7
Anti-IL-10 treatment abrogates beneficial effects of IL-37 on atherosclerosis. (A) Representative sections of aortic sinus stained with Oil Red O staining in ApoE−/− mice at 18 weeks. Black bar = 200 μm. n = 12. (B) Through (D) Quantitative analysis of lesion size, MOMA-2, and α-SMA staining. (E) Levels of plasma neutralizing antibodies of anti-IL-10R IgG. Values are presented as the mean ± SEM, n = 6. MOMA indicates monocyte/macrophage; SMA, smooth muscle actin. *p < 0.05, and **p < 0.01.
