Figure 2
From: Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
Aβ 1-42 levels in neocortex and hippocampus in APP/PS1 mice across differential housing conditions. (A) Overall, there was a significant effect of housing condition on cortical Aβ 1-42 levels, F(2, 12) = 10.41, p = 0.002. Follow-up post-hoc tests were performed with Bonferroni correction applied. The EE+ group had significantly higher cortical Aβ 1-42 compared with both SH (p = 0.003) and EE (p = 0.012). (B) No significant differences were detected in hippocampal Aβ 1-42 levels between housing conditions, F(2, 12) = 0.04, p = 0.96. SH (n = 5), EE (n = 5), EE+ (n = 5) *p < 0.05, **p < 0.01, ***p < 0.001.
