Figure 1
From: The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy
IL-38 inhibits developmental angiogenesis. (a) Neonatal mice were intraperitoneally administrated with IL-38 (1 ng per gram bodyweight) from P1 to P4. Vascular area of the retina whole mounts was assessed by fluorescence microscopy. The retina whole mounts and vascular area were respectively delineated by green and red boundary line. Scale bars, 500 μm. (b) Vascular area and relative vascular area from control group and IL-38-treated group were summarized; n = 8. (c) High-magnification images of retinal vasculature from control mice (top) or IL-38-treated mice (bottom). (d) Densities of tip cells (white arrow) and branching points were quantified. Data from 8 animals were summarized in the graphs. Scale bar, 50 μm. Data are presented as mean ± SEM. *P < 0.05 Student t test.
